Gout and Heart Disease News Roundup
Findings surrounding the possible role of gout as a risk factor for heart disease are mixed. The evidence for an association between inflammatory diseases such as rheumatoid arthritis and cardiovascular disease (CVD) is more robust, yet there are data that link hyperuricemia, the primary metabolic abnormality in gout, with higher risk of CVD. Elevated serum urate leads to acute joint inflammation and is associated with endothelial dysfunction, a known precursor to atherogenic disease. Hyperuricemia has also been identified as a risk factor for peripheral vascular disease, another manifestation of atherosclerosis.
The following short slide show reviews several recent studies that also suggest a link between the crystal-induced arthropathy and heart disease. What do you see in your practice?